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Evolution of DNA and RNA as catalysts for chemical reactions

Journal

CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 4, Issue 3, Pages 257-262

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(00)00086-7

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In vitro selection from combinatorial nucleic acid libraries has provided new RNA and DNA molecules that have catalytic properties. Catalyzed reactions now go far beyond self-modifying reactions of nucleic acid molecules. The future application of in vitro selected RNA and DNA catalysts in bioorganic synthesis appears promising.

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