Journal
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 12, Issue 3, Pages 376-384Publisher
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.neuropsych.12.3.376
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Repetitive transcranial magnetic stimulation (rTMS) is a fool with antidepressant potential that uses a coil placed on the scalp to produce a powerful magnetic field that directly stimulates only the outermost cortex. MRI scans weve obtained in 29 depressed adults involved in an rTMS antidepressant clinical treatment. These scans were analyzed to investigate the effect of distance from coil to cortex on clinical parameters. Longer motor cortex distance, but not prefrontal distance, strongly correlated with increased motor threshold (P < 0.01). Clinical antidepressant response did not correlate with either distance. The rTMS antidepressant responders, however, were significantly younger (t = -2.430, P < 0.05), and there appears to be a maximum threshold of age and distance to prefrontal cortex for response.
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