Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 6, Pages 294-299Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01597-8
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Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.
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