Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 19, Issue 8, Pages 1197-1203Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2013.05.020
Keywords
Unrelated donor transplantation; Ethnicity; Acute Graft-versus-host disease; Leukemia relapse
Categories
Funding
- Ministry of Health, Labor and Welfare, Japan [H23-Immunology-010]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [3224-22133011]
- National Institutes of Health, Bethesda, Maryland [AI069197, CA100019, CA18029, CA76518]
- Health Resources and Services Administration, Rockville, Maryland, USA [HHSH234200637015C]
- Office of Naval Research, Arlington, Virginia, USA [N00014-10-1-0204, N00014-1-1-0339]
- Grants-in-Aid for Scientific Research [22133011] Funding Source: KAKEN
Ask authors/readers for more resources
The significance of patient and donor ethnicity on risk of acute graft-versus-host disease (GVHD) and disease relapse after unrelated donor hematopoietic cell transplantation (HCT) is not known. A total of 4335 patient-donor pairs from the International Histocompatibility Working Group in HCT met the following 3 criteria: (1) HLA-A, -B, -C, -DRB1, and -DQB1 allele matched donor, (2) diagnosis of leukemia, and (3) non-T cell depleted GVHD prophylaxis. Posttransplantation risks of acute GVHD and leukemia relapse were defined in Asian/Pacific Islander, white, African American, Hispanic, and Native American patients that underwent transplantation from donors with the same self-described background. Asian patients had a significantly lower incidence of acute GVHD (Japanese patients: 40.0% grades II to IV and 15.3% grades III to IV; non-Japanese Asian patients: 42.1% grades II to IV and 15.7% grades III to IV) compared with white patients (56.5% grades II to IV and 22.6% grades III to IV) (P < .001). The hazard ratio of acute GVHD for white patients was significantly higher than for Japanese patients. Unexpectedly, the hazard ratio of leukemia relapse in white patients with early disease status was also significantly higher than that in Japanese patients. These results provide a platform for future investigation into the genetic factors for unrelated donor HCT and clinical implications of diverse ethnic background. (C) 2013 American Society for Blood and Marrow Transplantation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available