Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 32, Issue 3, Pages 237-246Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1005532912212
Keywords
NDP kinase; ping-pong mechanism; phosphohistidine; substrate-assisted catalysis; nucleotide analog
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Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance of in vitro studies.
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