Journal
MOLECULAR GENETICS AND METABOLISM
Volume 70, Issue 2, Pages 159-161Publisher
ACADEMIC PRESS INC
DOI: 10.1006/mgme.2000.2999
Keywords
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Funding
- NIDDK NIH HHS [R01 DK44073, R01 DK56210] Funding Source: Medline
- NIMH NIH HHS [P01MH43880] Funding Source: Medline
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We screened the peroxisome proliferator activated receptor gamma(2) (PPAR gamma 2) for sequence variants in 165 unrelated obese (BMI greater than or equal to 30 kg/m(2)) Caucasian women, and 49 normal weight Caucasian female controls (BMI < 27 kg/m(2)). The allele frequency of the Pro12Ala mutation was higher in obese(18.18%) than in normal weight women (8.16%) (chi((1))(2) = 5.68, P = 0.017). Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9.4 years; Pro/Ala + Ala/Ala 8.6 +/- 7.1 years, P = 0.005), was associated with lower fasting glucose and was protective against type II diabetes. (C) 2000 Academic Press.
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