Journal
JOURNAL OF BACTERIOLOGY
Volume 182, Issue 11, Pages 3278-3280Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.11.3278-3280.2000
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Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1 strains. We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production.
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