4.2 Article

Dimebon improves learning in animals with experimental Alzheimer's disease

Journal

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 129, Issue 6, Pages 544-546

Publisher

CONSULTANTS BUREAU
DOI: 10.1007/BF02434871

Keywords

dimebon; H-1 receptor inhibitor; tacrine; AF64A; avoidance conditioning; rats

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Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.

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