Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 57, Issue 6, Pages 976-981Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/PL00000738
Keywords
CC16; reverse-phase HPLC; asthma; BAL fluid proteins
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The Clara cell 16 kDa protein (CC16) maps to an atopy-associated region of chromosome ii and has been ascribed an anti-inflammatory function. Using reverse-phase HPLC and Western blot analysis, we have evaluated the polypeptide pattern in bronchoalveolar lavage (BAL) fluid retrieved from asthmatics, before and after induction of airway inflammation by low-dose allergen inhalation challenge. A prominent decrease of CC16 was seen after induction of inflammation, and a further CC16 decrease was observed in lavage fluid where surfactant had been removed. Reduced levels of pulmonary CC16 may cause loss of anti-inflammatory activity in the airways and contribute to the development of airway inflammation in asthma.
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