Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 130, Issue 4, Pages 713-716Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjp.0703372
Keywords
L-citrulline; L-arginine; 3-morpholinosydnonimine hydrochloride (SIN-1); vascular smooth muscle; relaxation
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1 The study was prompted by the report of Ruiz E. & Tejerina T., 1998 describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. 2 We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. 3 No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10(-12) to 10(-3) M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10(-6) M) relaxed vascular tissues. 4 This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle.
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