Journal
INFECTION AND IMMUNITY
Volume 68, Issue 6, Pages 3344-3348Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.6.3344-3348.2000
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Funding
- NIAID NIH HHS [R37 AI027998, R01 AI039614, AI39614, R01 AI027998, AI27998] Funding Source: Medline
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Resolution of infection with attenuated Salmonella is an active process that requires CD4(+) T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28(+) CD4(+) T tells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4(+) T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.
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