Journal
CYTOKINE
Volume 12, Issue 6, Pages 742-746Publisher
W B SAUNDERS CO
DOI: 10.1006/cyto.1999.0623
Keywords
CD137; activation-induced cell death; apoptosis; lymphocyte
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CD137 is a member of the tumour necrosis factor receptor family which delivers a potent co-stimulatory signal to T lymphocytes, Soluble forms of CD137 (sCD137) can be found at enhanced levels in sera of patients with rheumatoid arthritis. Here we show that expression of sCD137 lags behind that of membrane-bound CD137 (mCD137) by about 24h, In fully activated lymphocytes, time of maximum increase and level of expression of sCD137 were at day 2 and 3, respectively, Expression of sCD137 in lymphocytes requires strong activation, and levels of sCD137 correlate negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. Since activation of lymphocytes through membrane-bound CD137 delivers a potent stimulatory signal, sCD137 may provide a negative control mechanism for immune responses. (C) 2000 Academic Press.
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