Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 66, Issue 2, Pages 425-428Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0091-3057(99)00264-6
Keywords
pentylenetetrazol; kindling; microdialysis; dopamine; rat
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Kindling-induced activation of dopaminergic neurones in the nucleus accumbens in pentylenetetrazol (PTZ)-kindled rats was studied using microdialysis. Dopamine (DA) release after PTZ challenge was measured: (1) two weeks and (2) ten weeks after kindling completion and (3) two weeks after a kindling procedure with diazepam (DZP) treatment. In (1) a significant increase in DA concentration was found after PTZ challenge and this increase was still evident 10 weeks after kindling completion (2). Coadministration of DZP in the course of kindling development inhibited the increase in sensitivity of the accumbens dopaminergic system (3). (C) 2000 Elsevier Science Inc.
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