Journal
NATURE GENETICS
Volume 25, Issue 2, Pages 166-172Publisher
NATURE AMERICA INC
DOI: 10.1038/76014
Keywords
-
Categories
Funding
- NCI NIH HHS [CA71692, CA08748] Funding Source: Medline
Ask authors/readers for more resources
The promyelocytic leukaemia zinc finger (Plzf) protein (encoded by the gene Zfp 145) belongs to the POZ/zinc-finger family of transcription factors. Here we generate Zfp 145(-/-) mice and show that Plzf is essential for patterning of the limb and axial skeleton. Plzf inactivation results in patterning defects affecting all skeletal structures of the limb, including homeotic transformations of anterior skeletal elements into posterior structures. We demonstrate that Plzf acts as a growth-inhibitory and pro-apoptotic factor in the limb bud. The expression of members of the abdominal b (Abdb) Hox gene complex, as well as genes encoding bone morphogenetic proteins (Bmps). is altered in the developing limb of Zfp 145(-/-) mice. Plzf regulates the expression of these genes in the absence of aberrant polarizing activity and independently of known patterning genes. Zfp145(-/-) mice also exhibit anterior-directed homeotic transformation throughout the axial skeleton with associated alterations in Hox gene expression. Plzf is therefore a mediator of anterior-to-posterior (AP) patterning in both the axial and appendicular skeleton and acts as a regulator of Hox gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available