Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 105, Issue 1, Pages 31-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(00)00205-8
Keywords
IL-10; catecholamines; immunodepression; neuroendocrinoimmunology; IL-10 promoter; cAMP
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Acute stress reactions (e.g. linked with trauma, major surgery, psychic stress and myocardial infarction) are accompanied with temporary systemic release of the anti-inflammatory cytokine IL-10 followed by immunodepression. Since an association between activation of the sympathetic system and IL-10 release has been described, we studied the influence of catecholamines on its promoter activity in vitro. Using reporter gene assays we demonstrated that catecholamines in monocytic cells directly stimulate the IL-10 promoter/enhancer via a cAMP/protein kinase A-dependent pathway. A cAMP responsive element was identified as major target. Thus, catecholamines are directly involved in the regulation of immunoresponsiveness under stressful conditions. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
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