Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 17, Issue 8, Pages 1099-1111Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2011.02.013
Keywords
Bone marrow; Graft-versus-tumor; Human leukocyte antigen compatibility; Targeted therapy
Categories
Funding
- Major Science and Technology Program of Zhejiang Province [2006C13022]
- Health Professions Scientific Research Program [200802027]
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Haploidentical hematopoietic stem cell transplantation (HSCT) is a potentially curative therapeutic regimen that could increase donor availability to nearly 100%. Rapid advances in medical technology and the application of novel drugs mean that most haploidentical HSCT-associated complications can now be prevented or remarkably well controlled, even cured. However, relapsing hematologic malignancy remains a major cause of death in haploidentical HSCT recipients. Haploidentical HSCT should theoretically trigger a more potent graft-versus-tumor effect compared with human leukocyte antigen-identical transplantation, due mainly to the major histocompatibility complex and minor histocompatibility anitigen disparities on donors' immune cells and recipients' tumor cells. The underlying mechanisms of such relapsing hematologic malignancies remain elusive. In this review, we suggest correlating factors and potential mechanisms and examine feasible therapeutic and preventive strategies for relapsing hematologic malignancies after haploidentical HSCT Biol Blood Marrow Transplant 17: 1099-1111 (2011) (C) 2011 American Society for Blood and Marrow Transplantation
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