Journal
EXPERIMENTAL NEUROLOGY
Volume 163, Issue 2, Pages 388-391Publisher
ACADEMIC PRESS INC
DOI: 10.1006/exnr.2000.7393
Keywords
hyperphosphorylation; interleukin-1; neurofibrillary tangles; neurofilaments; tau
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Funding
- NIA NIH HHS [P01 AG012411, AG 10208, AG 12411] Funding Source: Medline
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Slow-release, IL-1-impregnated pellets implanted in rat cerebral cortex to simulate chronic overexpression of IL-1 significantly increased relative tissue levels of tau mRNA and of tau immunoreactivity in neuronal cell bodies and in swollen dystrophic neurites that also overexpressed phosphorylated and nonphosphorylated neurofilament epitopes. in addition, rats with IL-1-impregnated pellets, but not control rats or those with sham pellets, showed focal immunoreactivity for hyperphosphorylated tau epitopes present in paired helical filaments. Our results are consistent with an important driving role for IL-1 in the pathogenesis of Alzheimer-type neuronal and neuritic changes. (C) 2000 Academic Press.
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