Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 16, Issue 3, Pages 403-412Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2009.11.006
Keywords
Bone marrow-derived mesenchymal stem cell; Chronic graft-versus-host disease; Sclerodermatous chronic graft-versus-host disease; Allogeneic hematopoietic cell transplantation
Categories
Funding
- Chinese Ministry of Science and Technology [2006AA02A109, 2006AA02A115]
- National Natural Science Foundation of China [30830052]
- Beijing Ministry of Science and Technology [D07050701350701]
- Cheung Kong Scholars
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The success of treatment for sclerodermatous chronic graft-versus-host disease (ScGVHD) remains disappointing. The immunomodulatory ability of bone marrow (BM) derived mesenchymal stem cells (MSCs) shows promise in treating GVHD, especially given its previous success in treating patients with acute GVHD (aGVHD). The potential efficacy and safety issues for treating cGVHD, particularly ScGVHD, remain to be clarified, however. Here, we report 4 patients with ScGVHD who received MSCs expanded ex vivo from unrelated donors by intra-BM injection. After MSC infusion, the ratio of helper T lymphocyte (Th) 1 cells to Th2 cells was dramatically reversed, with an increase in Th 1 and a decrease in Th2 achieving a new balance. Correspondingly, symptoms gradually improved in all 4 patients. During the course of MSC treatment, the patients' vital signs and laboratory results remained normal. At the time of this report, none of the 4 patients had experienced recurrence of leukemia. Although this study alone cannot guarantee the application of MSCs in ScGVHD, our findings strongly suggest that this treatment is therapeutically practicable, with no detectable side effects. This approach may provide new insight into the clinical treatment of ScGVHD, with the aim of greatly increasing the survival rate in patients with leukemia who undergo allogeneic BM transplantation (BMT). Biol Blood Marrow Transplant 16: 403-412 (2010) (C) 2010 American Society fir Blood and Marrow Transplantation
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