Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 15, Issue 3, Pages 370-376Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2008.12.491
Keywords
Graft-versus-host disease; Voriconazole; Phototoxicity; Fungal infection
Categories
Funding
- NIH, Center for Cancer Research, National Cancer Institute
- Clinical Research Training Program
- Pfizer Inc
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Systemic fungal infections pose a significant risk to patients following allogeneic hematopoietic cell transplantation (alloHCT). Voriconazole (Vfend (R), Pfizer) is an oral second-generation triazole antifungal agent that offers a broad spectrum of coverage against fungal species and is frequently utilized in the post-HCT setting. Herein, we describe 5 patients who were initially believed to be experiencing a flare of cutaneous chronic graft-versus-host disease (cGVHD), but who were actually exhibiting phototoxicity caused by voriconazole. A high index of suspicion for this adverse reaction in the post-alloHCT setting will prevent misdiagnosis and avoid inappropriate therapy for cGVHD.
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