Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 4, Issue 3, Pages 324-337Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(00)00096-X
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There has been a wealth of recent reports concerning support-bound reagents and scavengers in the solution-phase synthesis of compound libraries and natural products. Important advances in 1999 include the continued development and use of novel reagents for heterocycle synthesis, the increased use of catch-and-release purification, and the development of increasingly sophisticated techniques to allow sequestering of many types of impurities from desired compounds. These techniques have all been combined to enable the complicated multistep synthesis of natural products and of libraries of novel drug-like molecules, without conventional purification.
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