Journal
JOURNAL OF PSYCHOPHARMACOLOGY
Volume 14, Issue 2, Pages 100-113Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/026988110001400201
Keywords
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolaproprionate); dorsal raphe nucleus (DRN); excitatory amino acid (EAA); GABA (gamma-aminobutyric acid); glutamate; median raphe nucleus (MRN); microdialysis; nucleus accumbens (NAcc); serotonin (5-HT); NMDA (N-methyl-D-aspartate)
Funding
- NIMH NIH HHS [MH51080] Funding Source: Medline
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Regulation of serotonin release by gamma-aminobutyric acid (GABA) and glutamate was examined by microdialysis in unanaesthetized rats. The GABA(A) receptor agonist muscimol, or the glutamate receptor agonists kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolapr or N-methyl-D-aspartate were infused into the dorsal raphe nucleus (DRN) while extracellular serotonin was measured in the DRN and nucleus accumbens. Muscimol produced decreases, and the glutamate receptor agonists produced increases in serotonin. To determine if these receptors have a tonic influence on serotonergic neurons, glutamate or GABA(A) receptor antagonists were infused into the DRN. Kynurenate, a nonselective glutamate receptor blocker, produced a small, 30% decrease in serotonin. A similar decrease was obtained with combined infusion of AP-5 and DNQX into the DRN. The GABA(A) receptor blocker bicuculline produced an approximately three-fold increase in DRN serotonin. In conclusion, glutamate neurotransmitters have a weak tonic excitatory influence on serotonergic neurons in the rat DRN. However, the predominate influence is mediated by GABA(A) receptors.
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