4.2 Article

A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma

Journal

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 14, Issue 11, Pages 1253-1261

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2008.08.011

Keywords

Hodgkin lymphoma; Hematopoietic stem cell mobilization; AMD3100; Plerixafor

Funding

  1. American Society of Hematology
  2. Genzyme Corporation

Ask authors/readers for more resources

Collection of an adequate number of hematopoietic stem cells can be difficult in patients with relapsed or refractory Hodgkin lymphoma (HL) who are candidates for autologous stem cell transplantation (ASCT). Plerixafor (AMD3100), an inhibitor of the interaction between stromal cell-derived factor I (SDF-1) and its receptor CXCR4, is an effective hematopoietic stem cell mobilization agent in patients with multiple myeloma and non-Hodgkin lymphoma (NHL). This study was undertaken to investigate the efficacy and safety of hematopoietic stem cell mobilization with plerixafor in patients with HL. Twenty-two patients with HL who were candidates for ASCT underwent hematopoietic stem cell mobilization with a combination of granulocyle-colony stimulating factor (G-CSF), 10 mu g/kg daily, and plerixafor, 240 mu g/kg subcutaneous, 10-11 hours prior to apheresis. The primary endpoint was the proportion of patients who collected >= 5 x 10(6) CD34(+) cells/kg. Outcomes were compared to a historical control population of HL patients mobilized with G-CSF alone. Pharmacokinetic (PK) analysis of plerixafor was performed in a subset of patients. Fifteen patients (68%) collected >= 5 x 10(6) CD34(+) cells/kg, and 21 patients (95%) achieved the minimum collection of; >= 2 x 10(6) CD34(+) cells/kg, in a median 2 apheresis procedures. Both the proportion of patients collecting >= 5 x 10(6) CD34(+) cells/kg and the median CD34(+) cells collected in days 1-2 of apheresis were significantly improved over historical controls. The PK of plerixafor in this patient population was similar to that previously seen in healthy volunteers. The regimen was generally safe and well tolerated.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available