Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 59, Issue 6, Pages 544-558Publisher
AMER ASSN NEUROPATHOLOGISTS INC
DOI: 10.1093/jnen/59.6.544
Keywords
allelotype; brain; molecular genetics; mutation; tumor
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Funding
- NCI NIH HHS [CA57683] Funding Source: Medline
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Brain tumors pose a particular challenge to molecular oncology. Many different tumor entities develop in the nervous system and some of them appear to follow distinct pathogenic routes. Molecular genetic alterations have increasingly been reported in nervous system neoplasms. However. a considerable number of affected genes remain to be identified. We present here a comprehensive allelotype analysis of 466 nervous system tumors based on loss of heterozygosity (LOH) studies with 129 microsatellite markers that span the genome. Specific alterations of the EGFR. CDK4. CDKN2A, TP53. DMBTI. NF2, and PTEN genes were analyzed in addition. Our data point to several novel generic loci associated with bl ain tumor development, demonstrate relationships between molecular changes and histopathological features. and further expand the concept of molecular tumor variants in neuro-oncology. This catalogue may provide a valuable framework Tol future studies to delineate molecular pathways in many types of human central nervous system tumors.
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