Journal
IMMUNITY
Volume 12, Issue 6, Pages 665-676Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(00)80217-4
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Funding
- NHLBI NIH HHS [HL54936, HL48675, HL56949] Funding Source: Medline
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Noninflamed skin venules support constitutive leukocyte rolling. P-selectin controls the rolling frequency, whereas E-selectin dictates rolling velocity (V-roll). Fucosylated selectin ligands are essential for all interactions, as rolling was absent in mice doubly deficient in alpha 1,3-fucosyltransferase (FucT)-IV and FucT-VII. The rolling fraction was reduced in FucT-VII-/- animals but normal in FucT-IV-/- mice. However, V-roll was markedly increased in both strains. P-selectin ligands generated by FucT-VII are crucial for initial leukocyte tethering, whereas E-selectin ligands that permit maximum slowing of V-roll require simultaneous expression of FucT-IV and FucT-VII. These results demonstrate a role for FucT-IV in selectin-dependent adhesion and suggest that the endothelial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the skin.
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