Journal
TETRAHEDRON
Volume 56, Issue 23, Pages 3743-3748Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)00281-7
Keywords
alkaloids; antivirals; indoles; marine metabolites
Categories
Ask authors/readers for more resources
A new bromoindole alkaloid, named dragmacidin F (1) and structurally related to other dragmacidins previously described, was isolated from a marine sponge of the genus Halicortex collected off the southern coast of Ustica Island (Italy). Structural elucidation of 1 was achieved by an extensive spectroscopic study (mainly by 1D/2D-NMR and MS techniques). Compound 1, containing an unprecedented carbon skeleton that is very likely derived from cyclization of a partially oxidized form of dragmacidin D (2), showed in vitro antiviral activity against HSV-1 (EC50=95.8 mu M) and HIV-1 (EC50=0.91 mu M), thus proving to be responsible for the antiviral property exhibited by Halicortex extracts. (C) 2000 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available