Journal
NEUROREPORT
Volume 11, Issue 8, Pages 1625-1630Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200006050-00006
Keywords
amygdala; CREB; fear conditioning; insular cortex; learning; MAP kinase; taste aversion
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Funding
- NIMH NIH HHS [T32 MH18390] Funding Source: Medline
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Mice were subjected to a taste aversion conditioning procedure in which they drank water, familiar saccharin, or novel saccharin, followed by injection of either NaCl or the emetic agent LiCl. Immunohistochemistry was used to localize phosphorylated MAP kinase (ppERK) and phosphoCREB (pCREB) in the brain shortly after conditioning. An examination of insular cortex and amygdala revealed specific phosphorylation of MAP kinase by novel saccharin and LiCl, and CREB by LiCl. Pairing of novel saccharin with LiCl was the only stimulus sufficient to increase ppERK and pCREB immunoreactivity in the lateral amygdala, suggesting this as a site of CS-US convergence. ppERK immunoreactivity was localized to both nuclear and non-nuclear compartments, suggesting multiple functional roles of MAP kinase during learning. NeuroReport 11:1625-1630 (C) 2000 Lippincott Williams & Wilkins.
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