Journal
PHYSICAL REVIEW LETTERS
Volume 84, Issue 23, Pages 5443-5446Publisher
AMERICAN PHYSICAL SOC
DOI: 10.1103/PhysRevLett.84.5443
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Using a combination of the quartz crystal microbalance and surface plasmon resonance techniques, we have studied the spontaneous formation of supported lipid bilayers from small (similar to 25 nm) unilamellar vesicles. Together these experimental methods measure the amount of lipid adsorbed on the surface and the amount of water trapped by the lipid. With this approach, we have, for the first time, been able to observe in detail the progression from the adsorption of intact vesicles to rupture and bilayer formation. Monte Carlo simulations reproduce the data.
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