Journal
NEUROREPORT
Volume 11, Issue 8, Pages 1703-1708Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200006050-00022
Keywords
coincidence detection; lateral amygdala; oscillations; rhythmicity; spike doublets
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A majority of projection neurons in the lateral amygdala generate oscillatory spike firing in the theta-frequency range, largely due to intrinsic membrane properties. Here we report on the occurrence of spike doublets in about 70% of these cells. Spike doublets consisted of a fast initial and a second slower component, which were mediated by sodium- and calcium-dependent mechanisms, respectively. With increased level of depolarization, there was a gradual transition of fast action potentials, regular alternation of fast action potentials and spike doublets, regular spike doublets, and high-threshold oscillations. Fast Fourier transforms demonstrated the rhythmic nature of spike doublers at around 3 Hz with an intra-doublet frequency of 25-80 Hz. Spike doublets may thus contribute to the overall rhythmicity in the membrane potential patterns of projection cells and support the integration of synaptic input signals. NeuroReport 11:1703-1708 (C) 2000 Lippincott Williams & Wilkins.
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