Journal
GENOMICS
Volume 66, Issue 3, Pages 229-241Publisher
ACADEMIC PRESS INC
DOI: 10.1006/geno.2000.6213
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Mechanically induced hypertrophy of skeletal muscles involves shifts in gene expression leading to increases in the synthesis of specific proteins. Full characterization of the regulation of muscle hypertrophy is a prerequisite for the development of novel therapies aimed at treating muscle wasting (atrophy) in human aging and disease. Using suppression subtractive hybridization, cDNAs corresponding: to mRNAs that increase in relative abundance in response to mechanical stretch of mouse skeletal muscles in vivo were identified. A novel 1100-bp transcript was detected exclusively in skeletal muscle. This exhibited a fourfold increase in expression after 7 days of stretch. The transcript had an open reading: frame of 328 amino acids encoding an ATP/GTP binding domain, a nuclear localization signal, two PEST protein-destabilization motifs, and a 132-amino-acid ankyrin-repeat region, We have named this gene ankyrin-repeat domain 2 (stretch-responsive muscle) (Ankrd2), We hypothesize that Ankrd2 plays an important role in skeletal muscle hypertrophy. (C) 2000 Academic Press.
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