Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 65, Issue 12, Pages 3644-3651Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo991836r
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Funding
- PHS HHS [1R155959401] Funding Source: Medline
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Liposomes incorporating fluorescent, metal-chelating lipids find applications in molecular recognition of peptides, 2D protein recystallization, protein targeting, and biological sensing. It would be advantageous to combine the usefulness of polymerizable, metal-chelating lipids and fluorescent lipids. Herein, we report the synthesis and fluorescence properties of several fluorescent, polymerizable, metal-chelating lipids. They have been successfully incorporated into liposomes and then polymerized. These lipids can be used as membrane probes to study the polymerizable liposomes in the unpolymerized state and to investigate lipid redistribution during polymerization. In addition, if a luminescent metal ion (e.g., Eu3+, Tb3+, etc.) is used to complex the headgroup, the lipids can probe the membrane interior and exterior simultaneously.
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