Journal
AIDS
Volume 14, Issue 9, Pages 1155-1161Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200006160-00012
Keywords
blind T cell homeostasis; HIV; AIDS; CD4 cell count; progression; SI virus phenotype
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Funding
- NIAID NIH HHS [AI 34043, AI 37984] Funding Source: Medline
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Objective: To assess the association between T cell homeostasis and its failure and 1.) the occurence of AIDS and 2.1 the switch from the non-syncytium-inducing (NSI) to the syncytium-inducing (S1) HIV virus phenotype. Methods: For each of 325 homosexual men in the Amsterdam Cohort Study, the slope of the CD3 T cell count versus time was determined. The timing (T cell inflection point (IP)) and magnitude of the change in slope were correlated with the time of the NSI/SI switch. Results: Median T cell slopes before the IP (pre-IP) were nearly zero regardless of whether AIDS occurred; the slopes after the IP (post-IP) were associated with clinical outcomes, with a median annual decline of 17.6% among those who developed AIDS and increase of 4.6% in those remaining AIDS free. Among subjects considered to have a true IP (decline > 8.2%/year post-IP), the times of the SI switch and the IP slope were highly correlated (r = 0.65); among those with AIDS, the S1 switch preceded the IP by a median of 0.63 years. Conclusion: These results support the concept of blind T cell homeostasis and also suggest that HIV-1 SI variants play an important role in the failure of T cell homeostasis. (C) 2000 Lippincott Williams & Wilkins.
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