Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 164, Issue 1-2, Pages 1-4Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0303-7207(00)00263-X
Keywords
growth hormone; liver gene expression; transcription factors; HNF-6; HNF-4; C/EBP
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Growth hormone (GH) controls gene expression in liver. Recent work suggests that this can result in part from the stimulation by GH of the synthesis of liver-specific transcription factors, one of which is HNF-6. The liver-specific factors HNF-4 and C/EBP alpha respectively stimulate and inhibit transcription of the hnf 6 gene. Upon GH stimulation, the affinity of HNF-4 for the hnf 6 promoter is increased and the binding of C/EBP alpha is decreased. GH therefore controls hnf 6 by a combination of stimulatory and derepressive mechanisms. On the other hand, HNF-6 stimulates transcription of the hnf 3 beta and hnf 4 genes, the stimulation of hnf 4 resulting most likely from the GH-induced increase in HNF-6 concentration. We conclude that in liver GH is likely to control the synthesis of a whole set of proteins whose genes are regulated by a GH-sensitive network of transcription factors, which regulate each other by feed-back and autoregulatory loops. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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