Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 13, Pages 7313-7318Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.13.7313
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Funding
- NICHD NIH HHS [R01 HD025024, HD-25024, R03 HD34693] Funding Source: Medline
- NIDDK NIH HHS [T32 DK007296, R01 DK030579, P60 DK30579, R01 DK038495] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Mammalian preimplantation blastocysts exhibit insulin-stimulated glucose uptake despite the absence of the only known insulin-regulated transporter, GLUT4, We describe a previously unidentified member of the mammalian facilitative GLUT superfamily that exhibits approximate to 20-25% identity with other murine facilitative GLUTs. Insulin induces a change in the intracellular localization of this protein, which translates into increased glucose uptake into the blastocyst. a process that is inhibited by antisense oligoprobes. Presence of this transporter may be necessary for successful blastocyst development, fuel metabolism, and subsequent implantation. Moreover, the existence of an alternative transporter may explain examples in other tissues of insulin-regulated glucose transport in the absence of GLUT4.
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