Journal
SCIENCE
Volume 288, Issue 5474, Pages 2215-2219Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5474.2215
Keywords
-
Categories
Ask authors/readers for more resources
Mammalian kinetochores contain the centromere-specific histone H3 Variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. Here we report that the fission yeast homolog SpCENP-A is essential for establishing centromere chromatin associated with equal chromosome segregation. SpCENP-A binding to the nonrepetitious inner centromeres depended on Mis6, an essential centromere connector protein acting during G(1)-S phase of the cell cycle. Mis6 is likely required for recruiting SpCENP-A to form proper connection of sister centromeres.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available