Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 273, Issue 1, Pages 5-9Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.2897
Keywords
Alzheimer's disease; NADPH oxidase; p47-phox; p67-phox; amyloid beta; translocation; superoxide; microglia
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The present study is the first to show that superoxide (O-2(-)) forming NADPH oxidase is activated in Alzheimer's disease (AD) brains by demonstrating the marked translocation of the cytosolic factors p47-phox and p67-phox to the membrane. In conjunction with a recent in vitro study showing that amyloid beta activates O-2(-) forming NADPH oxidase in microglia, where these phox proteins are localized in this study, the present results suggest that, in AD, NADPH oxidase is activated in microglia, resulting in the formation of reactive oxygen species which can be toxic to neighboring neurons in AD. (C) 2000 Academic Press.
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