Journal
NEUROREPORT
Volume 11, Issue 9, Pages 1939-1943Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200006260-00026
Keywords
alcohol; cocaine; drug-seeking behavior; footshock stress; nociceptin; orphanin FQ; self-administration
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Funding
- NIAAA NIH HHS [AA10531] Funding Source: Medline
- NIDA NIH HHS [DA07348] Funding Source: Medline
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This study examined whether nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, can block drug-seeking behavior induced by footshock stress. Male Wistar rats were trained to operantly self-administer ethanol or cocaine, and then subjected to daily extinction training until responding ceased. Subsequent exposure to 15 min of intermittent footshock elicited robust reinstatement of responding at the previously drug-paired lever. NC (0.1-2.0 mu g; i.c.v.) significantly inhibited the effects of footshock stress on ethanol- but not cocaine-seeking behavior. The results support the hypothesis that the NC system participates in the regulation of behavioral responses to stress, and that drugs interacting with NC receptors may have therapeutic potential for the treatment of stress-induced alcohol-seeking behavior and relapse. NeuroReport 11:1939-1943 (C) 2000 Lippincott Williams & Wilkins.
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