Journal
NEUROREPORT
Volume 11, Issue 9, Pages 2013-2015Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200006260-00041
Keywords
addiction; drug self-administration; ibogaine; methamphetamine; 18-methoxycoronaridine; nicotine
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Funding
- NIDA NIH HHS [DA 03817] Funding Source: Medline
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In previous studies, 18-methoxycoronaridine (18-MC), a novel iboga alkaloid congener, has been found to decrease the intravenous self-administration of morphine and cocaine in rats. In the present study, 18-MC (1-40 mg/kg, i.p.) dose-dependently decreased the i.v. self-administration of methamphetamine and nicotine. As in the previous studies, drug self-administration was reduced for greater than or equal to 24 h after the highest dose of 18-MC. A comparison of 18-MC's interactions with all four drugs of abuse studied so far indicated that 18-MC is least effective in decreasing methamphetamine self-administration and most potent in decreasing nicotine self-administration. The results suggest that a nicotinic antagonist action of 18-MC contributes to its putative anti-addictive efficacy. NeuroReport 11:2013-2015 (C) 2000 Lippincott Williams & Wilkins.
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