Journal
ORGANIC LETTERS
Volume 2, Issue 13, Pages 1939-1941Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0060174
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Funding
- NCRR NIH HHS [S10 RR04981] Funding Source: Medline
- NIGMS NIH HHS [GM49975, GM44783] Funding Source: Medline
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The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.
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