Journal
FEBS LETTERS
Volume 476, Issue 1-2, Pages 55-57Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01670-7
Keywords
sphingosine-1-phosphate; EDG-1; sphingosine kinase; cell growth; apoptosis
Funding
- NCI NIH HHS [CA61774] Funding Source: Medline
- NIGMS NIH HHS [GM43880] Funding Source: Medline
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Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors, which now includes EDG-1, -3, -5, -6 and -8, SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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