Journal
INORGANICA CHIMICA ACTA
Volume 304, Issue 2, Pages 241-249Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0020-1693(00)00095-5
Keywords
antitumor activity; platinum complexes; bile acid complexes; diamine complexes
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This paper reports on new compounds, which consist of three functional parts - a transport fragment, a spacer and the biologically active compound. Cholic acid as transport fragment was linked via an alkyl spacer to a cisplatin analogue, representing the drug. The length of the alkyl chain was varied in order to investigate the influence of the distance between drug and transport fragment. Here we describe the synthesis and characterization of a series of complexes with the general formulae [PtCl(DMSO)(diamine)]Cl and [PtCl2(diamine)] (diamine = THP(CH2)(n)CH(CH2NH2)(2) and CholCOO(CH2)(n) CH(CH2NH2)(2) n = 4, 6, 8, 11). The compounds have been identified by elemental analysis, IR and NMR measurements. (C) 2000 Elsevier Science S.A. All rights reserved.
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