Journal
SCIENCE
Volume 288, Issue 5475, Pages 2379-2381Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5475.2379
Keywords
-
Categories
Funding
- NIDCD NIH HHS [DC02979] Funding Source: Medline
- NIDDK NIH HHS [DK09623] Funding Source: Medline
Ask authors/readers for more resources
With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body weight. We have identified a link between anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) Led to inhibition of feeding and dramatic weight Loss. C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl-coenzyme A. Thus, FAS may represent an important Link in feeding regulation and may be a potential therapeutic target.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available