Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 275, Issue 26, Pages 19719-19722Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M002843200
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Funding
- NIA NIH HHS [AG01228] Funding Source: Medline
- NIGMS NIH HHS [GM55871, GM47898] Funding Source: Medline
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Most normal diploid human cells do not express telomerase activity and are unable to maintain telomere length with ongoing cell divisions. We show that the length of the single-stranded G-rich telomeric 3'-overhang is proportional to the rate of shortening in four human cell types that exhibit different rates of telomere shortening in culture. These results provide direct evidence that the size of the G-rich overhang is not fixed but subject to regulation. The potential ability to manipulate this rate has profound implications both for slowing the rate of replicative aging in normal cells and for accelerating the rate of telomere loss in cancer cells in combination with anti-telomerase therapies.
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