Journal
BRAIN RESEARCH
Volume 869, Issue 1-2, Pages 241-243Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02392-1
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Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-IO in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 mu g/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS. (C) 2000 Elsevier Science BN. All rights reserved.
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