Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 10, Issue 5, Pages 188-192Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1050-1738(00)00066-9
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- NHLBI NIH HHS [R01 HL057170, HL57170] Funding Source: Medline
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Because triglycerides are considered essential for survival and their synthesis has been thought to occur through a single mechanism, inhibiting triglyceride synthesis has been largely unexplored as a possible target for obesity treatment. However; recent studies indicate that mice lacking acyl CoA:diacylglycerol acyltransferase (DGAT), a key enzyme in triglyceride synthesis, are viable and resistant to diet-induced obesity. Unexpectedly, this resistance is caused by a mechanism involving increased energy expenditure. These findings suggest that inhibiting specific components of triglyceride synthesis, such as DGAT is feasible and may represent a novel approach to treating obesity. (C) 2001, Elsevier Science Inc. All rights reserved.
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