Journal
BIOLOGY DIRECT
Volume 3, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1745-6150-3-54
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Funding
- French Centre National de la Recherche Scientifique
- Association de la Recherche contre le Cancer (ARC)
- Institut Universitaire de France (IUF)
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: DNA topoisomerase IB (TopoIB) was thought for a long time to be a eukaryotic specific enzyme. A shorter version was then found in viruses and later on in several bacteria, but not in archaea. Here, we show that a eukaryotic-like TopoIB is present in the recently sequenced genomes of two archaea of the newly proposed phylum Thaumarchaeota. Phylogenetic analyses suggest that a TopoIB was present in the last common ancestor of Archaea and Eucarya. This finding indicates that the last common ancestor of Archaea and Eucarya may have harboured a DNA genome.
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