Journal
ENDOCRINOLOGY
Volume 141, Issue 7, Pages 2608-2613Publisher
ENDOCRINE SOC
DOI: 10.1210/en.141.7.2608
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Funding
- NIA NIH HHS [AG-02331] Funding Source: Medline
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GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. We observed that mice homozygous for the disruption (-/-) were significantly smaller than normal wildtype (+/+) mice as well as mice heterozygous for the disruption, even at 1.5 yr of age. IGF-I levels were also significantly lower in the -/- mice and remained low as the mice aged. IGFBP-3 levels were severely reduced in the -/- mice, whereas IGFBP-1, -2, and -4 levels remained unchanged. Finally, the -/- mice lived significantly longer than +/+ and +/- mice. The latter result contradicts the anti-aging GN data and suggests the need for further analysis of GH and aging.
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