Journal
MICROBES AND INFECTION
Volume 2, Issue 8, Pages 945-954Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(00)00401-9
Keywords
malaria; Plasmodium falciparum; Saimiri monkey; fever; spleen; thrombocytopenia; anaemia
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Plasmodium falciparum infection in humans leads to a variety of symptoms ranging from an influenza-like syndrome to life-threatening complications. Animal models are useful tools for the detailed analysis of the interaction between both parasite and host factors leading to these various clinical manifestations. In this review, examining the different clinical, parasitological and haematological parameters associated with P. falciparum infection in spleen-intact monkeys, we propose this model as a good alternative for exploring some aspects of the host-parasite relationship in malaria. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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