Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 45, Issue 7, Pages 1383-1388Publisher
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1005564205755
Keywords
liver failure; hepatectomy; hepatitis; hepatocellular carcinoma; multivariate analysis
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The histologic activity of associated hepatitis was examined in 285 patients who underwent hepatectomy fur hepatocellular carcinoma (HCC), to determine if the histologic activity is an independent risk factor fur postoperative mortality due to liver failure. The proportion of patients with liver cirrhosis who died due to liver failure (6/1.80, 3.3%) was not different from that of patients with chronic hepatitis (2/68, 2.9%). However, mortality was higher in patients with liver cirrhosis and active hepatitis (4/46, 8.7%) than in those with cirrhosis and inactive hepatitis (2/134, 1.5%, P < 0.05). Such difference was not observed in the chronic hepatitis group. Multivariate analysis showed that clearance of indocyanine green at 15 min (ICGR15) and activity of hepatitis were two independent risk factors for postoperative mortality due to liver failure. In conclusion, histologic activity of associated hepatitis should be taken into account in hepatic resection of HCC in cirrhotic liver, in addition to the functional reserve of the liver.
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