Journal
PARASITOLOGY TODAY
Volume 16, Issue 7, Pages 282-286Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0169-4758(00)01698-7
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Trypanosomes are unable to synthesize the monosaccharide sialic acid, but some African trypanosomes American Trypanosoma cruzi can incorporate sialic acid derived from the host. To do so, T. cruzi expresses a trans-sialidase air enzyme that catalyzes the transfer of sialic acid from host glycoconjugates to mucin-like molecules located on the parasite surface membrane. The importance of the process is indicated by the fact that T. cruzi has hundreds of genes encoding trans-sialidase, trans-sialidase-like proteins and mucin core properties. Sequence divergence of members these families has resulted in some molecules having functions unrelated to the acquisition of sialic acid. In this article, Alberto Frasch reviews the structure and possible function of the proteins making up these families.
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