Journal
MAGNETIC RESONANCE IMAGING
Volume 18, Issue 6, Pages 689-695Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0730-725X(00)00147-8
Keywords
apparent diffusion coefficient; cell volume fraction; astrocytes; erythrocytes
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Diffusion-weighted imaging was used to study the relationship between apparent diffusion coefficient (ADC) and cell volume fraction in cell suspensions and packed arrays. Cell volume fraction was varied by changing extracellular fluid osmolarity (for human glial cells) and by changing cell density (far human glial and red blood cells). In packed arrays of glial cells, ADC increased 10% when cells shrank and decreased 13% when cells swelled. ADC decreased 34% as cell density increased from 0 to 72%. In erythrocyte suspensions, ADC decreased 90% as the cell density increased from 0 to 89%. These results agree with theoretical predictions. (C) 2000 Elsevier Science Inc. All rights reserved.
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